个人简介
姓名：顾杰
性别：男
出生年月：1982年11月
职称：副研究员
E-mail: 1000004531@ujs.edu.cn
学术简历
学习经历：
2001/09-2005/06，扬州大学，生物科学与技术，学士学位
2005/09-2008/06，扬州大学，生物化学与分子生物学，硕士学位
2009/03-2011/02，香港浸会大学，生物学，硕士学位
2011/07-2014/06，香港浸会大学，生物学，博士学位
工作经历：
2014/07-2015/06，香港浸会大学，生物系，助理研究员
2015/06-2016/08，pg电子官网入口，生命科学研究院，助理研究员
2017/09-至今，pg电子官网入口，生命科学研究院，副研究员
研究兴趣
重金属的分子毒理与解毒机制
钙离子稳态失衡相关疾病
环境污染与临床疾病相关研究
科研项目
国家自然科学基金青年基金，31600952，钙离子敏感受体CaSR的激活可减轻镉对肾小管上皮细胞的毒性的分子机理的研究，2017/01-2019/12，20万，结题，主持
香港General Research Fund项目，GRF 261610、 “The Identification of Stanniocalcin-1 Target Cells and the Characterization of the In-Situ Ca2+-Sensing and Transport Mechanisms in Gill Epithelial Cells of Japanese Eels”， 2010-2013，HK$986,000，已结题，参与
近年发表的论文
(1) Gu J, Ren Z, Zhao J, Peprah FA, Xie Y, Cheng D, Wang Y, Liu H, Chu Wong CK, Zhou Y, Shi H*. Calcimimetic compound NPS R-467 protects against chronic cadmium-induced mouse kidney injury by restoring autophagy process. Ecotoxicol Environ Saf. 2020, 189:110052.
(2) Gu J, Wang Y, Liu Y, Shi M, Yin L, Hou Y, Zhou Y, Chu Wong CK, Chen D, Guo Z, Shi H. Inhibition of Autophagy Alleviates Cadmium-Induced Mouse Spleen and Human B Cells Apoptosis. Toxicol Sci. 2019 Jul 1;170(1):109-122.
(3) Wang Y, Ji X, Dai S, Liu H, Yan D, Zhou Y, Gu J*, Shi H*. Cadmium induced redistribution of cholesterol by upregulating ABCA1 and downregulating OSBP. J Inorg Biochem. 2018 Dec;189:199-207.
(4) Gu J#, Dai S#, Liu H, Cao Q, Yin S, Lai KP, Tse WKF, Wong CKC, Shi H*. Identification of immune-related genes in gill cells of Japanese eels (Anguilla japonica) in adaptation to water salinity changes. Fish Shellfish Immunol. 2018 Feb;73:288-296.
(5) Gu J#, Dai S#, Liu Y, Liu H, Zhang Y, Ji X, Yu F, Zhou Y, Chen L, Tse WKF, Wong CKC, Chen B, Shi H*. Activation of Ca2+-sensing receptor as a protective pathway to reduce Cadmium-induced cytotoxicity in renal proximal tubular cells. Sci Rep. 2018 Jan 18;8(1):1092.
(6) Gu J#, Li JW#, Tse KF, Chan TF, Wong CK*. Transcriptomic responses of CS gland of Japanese eels (Anguilla japonica) to Changes in Water Salinity. Sci Rep. 2015, 5: 9836.
(7) Gu J, Law AY, Yeung BH, Wong CK*. Characterization of stanniocalcin 1 binding and signaling in gill cells of Japanese eels. J Mol Endocrinol. 2015, 54(3):305-314.
(8) Gu J, Law AY, Yeung BH, Wong CK*. Activation of gill Ca2+-sensing receptor as a protective pathway to reduce Ca2+-induced cytotoxicity. J Mol Endocrinol. 2014, 53(2):155-64.
(9) Gu J, Chan LS, Wong CK, Wong NS, Wong CK, Leung KN, Mak NK*. Effect of benzo[a]pyrene on the production of vascular endothelial growth factor by human eosinophilic leukemia EoL-1 cells. J Environ Pathol Toxicol Oncol. 2011, 30(3):241-249.
(10) Lai KP, Li JW, Gu J, Chan TF, Tse WK, Wong CK. Transcriptomic analysis reveals specific osmoregulatory adaptive responses in gill mitochondria-rich cells and pavement cells of the Japanese eel. BMC Genomics. 2015, 16:1072.
(11) Tse WK, Sun J, Zhang H, Lai KP, Gu J, Sheung Law AY, Yee Yeung BH, Ching Chow S, Qiu JW, Wong CK*. Data for transcriptomic and iTRAQ proteomic analysis of Anguilla japonica gills in response to osmotic stress. Data Brief. 2015, 3:120-125.
(12) Cao Q, Gu J, Wang D, Liang F, Zhang H, Li X, Yin S*. Physiological mechanism of osmoregulatory adaptation in anguillid eels. Fish Physiol Biochem. 2018 Apr;44(2):423-433
